货号：MAB3228

品牌：Merck Millipore

规格：100Ug

目录价：￥5887.00

市场价格：￥5003.95

会员价格：￥4709.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 5 Antibody, 8 | MAB3228 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Cytokeratin 5 and 8. MAB3228 is a broadly reacting cytokeratin antibody specific for cytokeratin 5 and cytokeratin 8. This antibody recognizes virtually all epithelial tissues and carcinomas. View All» Immunogen: Cytokeratins from the human lung cancer cell line MR21. View All» Isotype: IgG1 View All» Background Information: Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. View All» Species Reactivity:

• Canine

• Human

• Hamster

• Mouse

• Pig

• Rat

• Rabbit
  View All» Application Notes: Western blot Immunohistochemistry on frozen and paraffin embedded tissue sections. Immunocytochemistry Flow cytometry Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in buffer with 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:
  • P13647

  • P05787
    View All» Entrez Gene Number: NM_000424.3 View All» Gene Symbol:
    • KRT5

    • DDD

    • CK5

    • K5

    • EBS2

    • Keratin-5

    • KRT5A

    • Cytokeratin-5

    • CK-5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. View All» UniProt Summary: FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.SIZE: 483 amino acids; 53704 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin 5 Antibody, 8 | MAB3228 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Mesothelial cells, Epitheliod mesothelioma & Simple epithelial cells and all adenocarcinomas View All» Format: Purified View All» Host: Mouse View All»
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