货号：01-164

品牌：Merck Millipore

规格：

目录价：￥3726.00

市场价格：￥3167.10

会员价格：￥2980.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TNFα, recombinant View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: MW:17kDa View All» Key Applications: Cell Culture View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. View All» UniProt Summary: FUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.SIZE: 233 amino acids; 25644 Da SUBUNIT: Homotrimer.SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted.PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family. View All» Species: Human View All» Brand Family: Upstate View All» Source: Recombinant human TNFalpha, expressed in E. coli View All» Presentation: Lypholized from 3mM Tris, pH 8.0. View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:

• TNF

• TNFSF2

• Cachectin

• cachectin

• TNF-alpha

• DIF

• OTTHUMP00000037669

• TNFA

• TNF-a
  View All» Product Name: TNFα, recombinant View All» Quality Assurance: Routinely evaluated in a biological activity assay. View All» Physical Form: Lyophilized View All» UniProt Number: P01375 View All» Entrez Gene Number: NM_000594.2 View All» Purification Method: Sterilized through a 0.2 micron membrane filter View All»
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