货号：MAB3278

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Prosurfactant Protein B Antibody, clone 1-2-A5-9 | MAB3278 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human SP-B propeptide. View All» Immunogen: Human SP-B propeptide. View All» Clone: 1-2-A5-9 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: Immunoblot (non-reducing conditions only) ELISA Optimal dilutions must be determined by the end user. View All» Presentation: Liquid. Contains no preservative View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to twelve months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P07988 View All» Entrez Gene Number:

• NM_000542.2

• NM_198843.1
  View All» Gene Symbol:
  • SFTPB

  • SP-B

  • SFTP3

  • Phe

  • PSP-B

  • SFTB3

  • SMDP1
    View All» Alternate Names: proSP-B View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P07988 # Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.SIZE: 381 amino acids; 42117 Da SUBUNIT: Homodimer; disulfide-linked.SUBCELLULAR LOCATION: Secreted, extracellular space.DISEASE: SwissProt: P07988 # Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).SIMILARITY: SwissProt: P07988 ## Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). View All» Brand Family: Chemicon View All» Product Name: Anti-Prosurfactant Protein B Antibody, clone 1-2-A5-9 | MAB3278 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Pulmonary airways, Type II alveolar cells, adenocarcinomas w/ acinar, papillary, broncioloalveolar & solid growth patterns. View All» Format: Ascites View All» Host: Mouse View All»
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