货号：MAB3307

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5 | MAB3307 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specifically reacts with precursor and active forms of human MMP-1. View All» Molecular Weight: 52 kDa View All» Epitope: a.a. 332-350 hMMP1 View All» Immunogen: Syntheic peptide aa332-350 of hMMP-1 View All» Clone: 41-1E5 View All» Isotype: IgG2aκ View All» Species Reactivity:

• Human

• Rabbit
  View All» Application Notes: Immunoblotting: Immunohistochemistry on PLP fixed, paraffin-embedded tissues 5-20μg/ml. PLP fixation required for best results. Antibody also reacts with frozen tissues. Reactivity on tradional formalin fixed tissue is poor. Microwave antigen retrieval is recommended ElA View All» Control:
  • Cervical carcinoma

  • SKBr-3 cell lysate
    View All» Purification Method: Protein A purfied View All» Presentation: Liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P03956 View All» Entrez Gene Number: NM_002421.2 View All» Gene Symbol:
    • MMP1

    • CLG

    • MMP-1

    • CLGN

    • EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase

    • 27 kDa interstitial collagenase].
      View All» Alternate Names: Fibroblast Collagenase; Interstitial Collagenase View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
      • Manufactured by Daiichi Fine Chemical Co., Ltd

      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
        View All» Key Applications:
        • ELISA

        • Immunohistochemistry (Paraffin)

        • Western Blotting
          View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P03956 # Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 469 amino acids; 54007 Da SUBUNIT: Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P03956 There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases). & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5 | MAB3307 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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