货号：MAB331

品牌：Merck Millipore

规格：100UL

目录价：￥4368.00

市场价格：￥3712.80

会员价格：￥3494.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SNAP-25 Antibody, clone SP14 | MAB331 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: SNAP-25 (26-27 kDa). MAB331 is reactive with fusion protein from COS cells, but not with fusion protein from bacterial systems. View All» Immunogen: Crude synaptic immunoprecipitate (Human) View All» Clone: SP14 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Hamster

• Pig

• Rat
  View All» Application Notes: Immunohistochemistry at 1:500-1:5,000 Formalin fixed (* It is suggested that you use an IgG specific second antibody to minimize possible non-specific staining. Frozen Western blotting at 1:100-1:1,000 ELISA at 1:500 It is reported that clone SP14 is capable of detecting SDS-resistant SNARE complexes {J. Cell Sci 2004 117(6):955-966}. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid. Contains no preservative. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P60880 View All» Entrez Gene Number:
  • NM_003081.2

  • NM_130811.1
    View All» Gene Symbol:
    • SNAP25

    • SNAP

    • dJ1068F16.2

    • SNAP-25

    • FLJ23079

    • RIC-4

    • SUP

    • SEC9

    • RIC4

    • bA416N4.2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P60880 # t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.SIZE: 206 amino acids; 23315 Da SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1, SNAP25BP and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity).TISSUE SPECIFICITY: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.PTM: Palmitoylated (By similarity).SIMILARITY: SwissProt: P60880 ## Belongs to the SNAP-25 family. & Contains 2 t-SNARE coiled-coil homology domains. View All» Brand Family: Chemicon View All» Product Name: Anti-SNAP-25 Antibody, clone SP14 | MAB331 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Presynaptic View All» Format: Ascites View All» Host: Mouse View All»
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