货号：MAB3316

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-8 Antibody, clone 115-13D2 | MAB3316 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This is a purified mouse monoclonal antibody to human matrix metalloproteinase 8 (human MMP-8, neutrophil collagenase) from neutrophil. The antibody specifically reacts with latent (~85 kDa, reduced) and active (~67 kDa) forms of human MMP-8 by western blot. Does not cross-react with human MMP-1, 2, 3, 7, 9 and 13. It has been reported that this clone reacts with mouse MMP-8 (Balbin, 1998). View All» Epitope: Not Mapped View All» Immunogen: MMP-8 purified from human neutrophils. View All» Clone: 115-13D2 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Western blotting: 5-10 μg/mL: recognizes both latent (~85kDa reduced) and active (~67kDa) forms Immunohistochemistry: 10 μg/mL PLP fixed, paraffin-embedded tissue sections. Heat induced epitope retreival in citrate buffer, pH 6.0, is recommended. Also reacts with acetone or fresh frozen sections. Formalin fixation can be problematic and is not recommended. Optimal working dilutions must be determined by end user. View All» Control: Positive control cell line: PMNL cells View All» Presentation: Purified immunoglobulin presented as a liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Manufactured by Daiichi Fine Chemical Co., Ltd. Not available for sale in Japan. View All» UniProt Number: P22894 View All» Entrez Gene Number: NM_002424.1 View All» Gene Symbol:

• MMP8

• PMNL-CL

• MMP-8

• HNC

• CLG1

• EC 3.4.24.34
  View All» Alternate Names: Neutrophil Collagenase; Matrix Metalloproteinase 8 View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

  • Manufactured by Daiichi Fine Chemical Co., Ltd
    View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P22894 # Can degrade fibrillar type I, II, and III collagens.COFACTOR: Binds 3 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 467 amino acids; 53412 Da SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Stored in intracellular granules.TISSUE SPECIFICITY: Neutrophils.DOMAIN: SwissProt: P22894 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-8 Antibody, clone 115-13D2 | MAB3316 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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