货号：MAB3317

品牌：Merck Millipore

规格：1EA

目录价：￥5125.68

市场价格：￥4356.83

会员价格：￥4100.54

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7 | MAB3317 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human MMP-14, also known as MT1-MMP, with a very slight cross-reactivity to hMMP-3. For unknown reasons this antibody does not react on westerns to CC1043. View All» Molecular Weight: ~59-69 kDa View All» Epitope: a.a. 319-333 View All» Immunogen: CDGNFDTVAMLRGEM in the hemopexin-like domain of human MT1-MMP View All» Clone: 113-5B7 View All» Isotype: IgG3κ View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Application Notes: Western Blot: 10 μg/mL, membrane preparations; MD-MB-231 cells pretreated with 1-5 μg/mL ConA for 24-48 hours as positive control. 60-65 kDa proteins are identified. When tested against recombinant MT1-MMP (lacking the TM domain) expressed in CHO cells the antibody reacts with a band of ~59 kDa.Immunohistochemistry: Frozen tissue sections; traditional formalin fixation is problematic. Paraffin-embedded tissue sections with PLP fixation required.ImmunoprecipitationEIAOptimal working dilutions must be determined by the end user. View All» Control: Breast carcinoma tissue View All» Purification Method: Protein A purfied View All» Presentation: Purified immunoglobulin. Liquid in 0.1 M sodium phosphate buffer, pH 7.0, containing 2% protease-free bovine Serum albumin. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P50281 View All» Entrez Gene Number: NM_004995.2 View All» Gene Symbol:
  • MMP14

  • MTMMP1

  • MMP-14

  • MT1MMP

  • MT1-MMP

  • MMP-X1

  • EC 3.4.24.80
    View All» Alternate Names: MT1-MMP View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

    • Manufactured by Daiichi Fine Chemical Co., Ltd
      View All» Key Applications:
      • ELISA

      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. View All» UniProt Summary: FUNCTION: SwissProt: P50281 # Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).SIZE: 582 amino acids; 65884 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.DOMAIN: SwissProt: P50281 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7 | MAB3317 View All» Concentration: 4 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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