货号：MAB3324

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cathepsin K Antibody, clone 182-12G5 | MAB3324 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody MAB3324 is directed against a synthetic peptide corresponding to amino acids 182-195 of cathepsin K from human osteoarthritic hip bone. Specifically reacts with the human cathepsin K. View All» Clone: 182-12G5 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Immunoblotting. When used at a 2-5 μg/mL concentration to detect purified human cathepsin K from giant cell tumor at 0.7 μg/lane, this antibody detects a band at approximately 28 kDa. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in 0.1 M Sodium-Phosphate buffer, pH 7.0 containing 2% protease-free bovine serum albumin. No preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P43235 View All» Entrez Gene Number: NM_000396.2 View All» Gene Symbol:

• CTSK

• CTSO2

• CTSO

• CTSO1

• PKND

• CTS02

• PYCD

• MGC23107

• EC 3.4.22.38
  View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. View All» UniProt Summary: FUNCTION: SwissProt: P43235 # Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.SIZE: 329 amino acids; 36966 Da SUBCELLULAR LOCATION: Lysosome.TISSUE SPECIFICITY: Predominantly expressed in osteclasts (bones).DISEASE:SwissProt: P43235 # Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.SIMILARITY: SwissProt: P43235 ## Belongs to the peptidase C1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cathepsin K Antibody, clone 182-12G5 | MAB3324 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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