货号：MAB3328

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8 | MAB3328 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: LEM-2/15.8 reacts with human MT1-MMP and displays crossreactivity with mouse specimens. This antibody was generated against the catalytic domain of MT1-MMP and is able to inhibit enzyme activity. View All» Epitope: catalytic domain View All» Immunogen: Synthetic peptide: amino acid sequence 218-233 within the catalytic domain View All» Clone: LEM-2/15.8 View All» Isotype: IgG1κ View All» Background Information: MT1-MMP plays an important role during endothelial cell migration and matrix remodeling. Although the role of MT1-MMP in endothelial cell motility is not fully characterized, its activity appears to modulate endothelial migration, invasion, and formation of capillary tubes during the angiogenic response (Galvez, 2001). Mt1-MMP also appears to play a key role in monocyte revruitment during inflammation (Salomon, 2005). View All» Species Reactivity: Mouse View All» Application Notes: Western Blot Immunohistochemistry: Frozen and paraffin-embedded tissues Immunofluorescence Flow Cytometry Blocking: 10-15μg/mL Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin by Protein A chromatography . Liquid in 0.2M phosphate, 0.25M NaCl, pH 7.6, containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2° to 8°C for up to 12 months from date of receipt. View All» UniProt Number: P50281 View All» Entrez Gene Number: NM_004995.2 View All» Gene Symbol:

• MMP14

• MTMMP1

• MMP-14

• MT1MMP

• MT1-MMP

• MMP-X1

• EC 3.4.24.80
  View All» Alternate Names: MT1-MMP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. View All» UniProt Summary: FUNCTION: SwissProt: P50281 # Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).SIZE: 582 amino acids; 65884 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.DOMAIN: SwissProt: P50281 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8 | MAB3328 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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    © Merck Millipore代理MAB3328 Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8;抗MMP-14抗体，催化域，克隆LEM-2 / 15.8store at +2℃ to，产品报价联系微信jinshanbio