货号：MAB3418C3

品牌：Merck Millipore

规格：

目录价：￥4858.00

市场价格：￥4129.30

会员价格：￥3886.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP2 Antibody, clone AP20, Cy3 Conjugate | MAB3418C3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: The unconjugated parent antibody (Cat. No. MAB3418) has an observed molecular weight at ~230 kDa. View All» Immunogen: Bovine brain microtubule protein View All» Clone: AP20 View All» Isotype: IgG View All» Background Information: The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. View All» Species Reactivity:

• Rat

• Bovine

• Chicken

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat. Predicted to react with Bovine, Chicken, Human, and Mouse based on 100% sequence homology. View All» Control: Rat E18 primary cortex cells View All» Quality Assurance: Evaluated by Immunocytochemistry in rat E18 primary cortex cells.Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MAP2 in rat E18 primary cortex cells. View All» Purification Method: Protein A purified View All» Presentation: Purified mouse monoclonal IgG1 conjugated to Cy3 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: Q3ZC89 View All» Entrez Gene Number: NP_001035583 View All» Gene Symbol:
  • Map2

  • Mtap2
    View All» Alternate Names:
    • Microtubule-associated protein 2

    • MAP-2

    • MAP2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» Entrez Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. View All» UniProt Summary: FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.SIZE: 1827 amino acids; 199539 Da PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Contains 3 Tau/MAP repeats. View All» Product Name: Anti-MAP2, clone AP20, Cy3 Conjugate View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: CY3 View All» Host: Mouse View All»
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