货号：MAB3422

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone Antibody, clone H11-4 | MAB3422 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody binds specifically to an antigen determinant, which is present on all five histone proteins. The antibody recognizes the histones H1, H2A, H2B, H3 and H4 with comparable sensitivity. View All» Immunogen: Purified nuclear fractions of HeLa cells View All» Clone: H11-4 View All» Isotype: IgG1 View All» Background Information: There are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. Histones feature a main globular domain and a long N terminal tail which are involved with the structure of the nucleosomes of the 'beads on a string' structure. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation. View All» Species Reactivity:

• Mammals

• Human

• Bovine

• Rat

• Xenopus

• Opossum

• Hamster
  View All» Species Reactivity Note: Due to the highly conserved nature of histones, this antibody is predicted to have wide species reactivity. View All» Application Notes: Western Blot Analysis: 1:500 dilution of a previous lot was used.Immunocytochemistry: A 1-5 µg/mL concentration of a previous lot was used on Immunocytochemistry.Immunohistochemistry: A 1-5 μg/mL concentration of a previous lot was used on Immunohistochemistry.Optimal working dilutions must be determined by end user. View All» Control: All tissue View All» Quality Assurance: Routinely evaluated by Western Blot on Jurkat lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing 0.02M phosphate buffer, pH 7.6 with 0.25M NaCl and 0.1% sodium azide View All» Storage Conditions: Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt. The Iyophilized antibody is stable at 2–8°C. Store the reconstituted antibody in aliquots at -15 to -25°C for up to 12 months.Repeated freezing and thawing should be avoided. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunocytochemistry

  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. View All» Brand Family: Chemicon View All» Product Name: Anti-Histone Antibody, clone H11-4 | MAB3422 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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