货号：MAB342A4

品牌：Merck Millipore

规格：100UL

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor®488 Conjugate | MAB342A4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold to a lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells. View All» Molecular Weight: The unconjugated parent antibody (Cat. No. MAB342) has an observed molecular weight at ~75 kDa. View All» Immunogen: Synaptic plasma membranes from bovine hippocampus. View All» Clone: mGalC View All» Isotype: IgG3 View All» Background Information: Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Chicken
  View All» Species Reactivity Note: Demonstrated to react with Rat. Predicted to react with Mouse, Human, and Chicken. Predicted to react with Bovine based on immunogen design. View All» Control: Rat oligodendrocyte cells View All» Quality Assurance: Evaluated by Immunocytochemistry in rat oligodendrocyte cells.Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Galactocerebroside in rat oligodendrocyte cells. Performed without Triton. View All» Purification Method: Protein A purified View All» Presentation: Purified mouse monoclonal IgG3 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P54803 View All» Entrez Gene Number: NP_000144 View All» Gene Symbol: GALC View All» Alternate Names:
  • Galactocerebrosidase

  • GALCERase

  • Galactocerebroside beta-galactosidase

  • Galactosylceramidase

  • Galactosylceramide beta-galactosidase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» Entrez Gene Summary: This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.SIZE: 669 amino acids; 75147 Da SUBCELLULAR LOCATION: Lysosome.TISSUE SPECIFICITY: Highest level of activity in testes compared to brain, kidney, placenta and liver. Can also be found in urine.DISEASE: Defects in GALC are the cause of globoid cell leukodystrophy (GLD) [MIM:245200]; also known as Krabbe disease. This autosomal recessive disorder results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. Clinically, the most frequent form is the infantile form. Most patients (90%) present before six months of age with irritability, spasticity, arrest of motor and mental development, and bouts of temperature elevation without infection. This is followed by myoclonic jerks of arms and legs, oposthotonus, hypertonic fits, and mental regression, which progresses to a severe decerebrate condition with no voluntary movements and death from respiratory infections or cerebral hyperpyrexia before 2 years of age. However, a significant number of cases with later onset, presenting with unexplained blindness, weakness and/or progressive motor, and sensory neuropathy that can progress to severe mental incapacity and death, have been identified.SIMILARITY: Belongs to the glycosyl hydrolase 59 family. View All» Product Name: Anti-Galactocerebroside, clone mGalC, Alexa Fluor®488 Conjugate View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-131103.htm
    © Merck Millipore代理MAB342A4 Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor®488 Conjugate;store at +2℃ to +8℃，产品报价联系微信jinshanbio