货号：04-002

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SOCS1 Antibody, clone 4H1 | 04-002 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes SOCS1 View All» Molecular Weight: 37 kDa View All» Immunogen: mouse SOCS1 recombinant GST fusion protein encompassing amino acids 2-78. View All» Clone: 4H1 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunoblot Analysis: 1:1,000 dilution of this antibody detected SOCS1 in KG-1 cell lysate. Immunoprecipitation (IP): 10 μg of this antibody immunoprecipitated SOCS1 from 200 μL of cell extract in RIPA buffer. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein G purfied View All» Storage Conditions: 2 years at -20°C from date of shipment. View All» UniProt Number: O15524 View All» Entrez Gene Number: NM_003745.1 View All» Gene Symbol:
  • SOCS1

  • SSI-1

  • Cish1

  • TIP-3

  • TIP3

  • CISH1

  • SSI1

  • CIS1

  • SOCS-1

  • JAB
    View All» Alternate Names: suppressor of cytokine signaling 1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. View All» UniProt Summary: FUNCTION: SwissProt: O15524 # SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate-recognition component of a SCF- like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.SIZE: 211 amino acids; 23551 Da SUBUNIT: Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(VHL) E3 ubiquitin ligase complex which contains Elongin BC complex, CUL5, RBX1 and SOCS1 (By similarity). Interacts with TRIM8 (By similarity). Interacts with CUL2.TISSUE SPECIFICITY: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.DOMAIN: SwissProt: O15524 The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. & The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).SIMILARITY: Contains 1 SH2 domain. & Contains 1 SOCS box domain. View All» Brand Family: Upstate View All» Product Name: Anti-SOCS1 Antibody, clone 4H1 | 04-002 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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