货号：MAB3507

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caspase 2 Antibody, clone 11B4 | MAB3507 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB3507 antibody recognizes a reactive epitope that lies in the P19 subunit of human Caspase-2 (ICH-1, Nedd-2). View All» Immunogen: Raised against the P19 subunit of recombinant human Caspase-2 protein. View All» Clone: 11B4 View All» Isotype: IgG2a View All» Species Reactivity:

• Canine

• Human

• Mouse

• Monkey
  View All» Application Notes: Western blot: Recommended usage at 5 μg/ml, which has been found to detect endogenous Caspase-2 in 5 x 10E5 HeLa and MCF-7 cells. Immunoprecipitation: Recommended concentration 1-5 μg/ml FACS: Recommended concentration 1 μg/ml. It is necessary to permeabilize the cell membrane prior to analysis. EIA: Recommended concentration 0.5-1 μg/ml. Immunohistochemistry: Use at 10-20 μg/ml. It is necessary to fix the cells in 4% Paraformaldehyde/0.18% Triton-X100 for 10 minutes prior to staining. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid with 0.05% Bronidox as a preservative. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P42575 View All» Entrez Gene Number:
  • NM_032982.2

  • NM_032983.2
    View All» Gene Symbol:
    • CASP2

    • NEDD2

    • ICH1

    • NEDD-2

    • ICH-1L/1S

    • CASP-2

    • ICH-1L

    • EC 3.4.22.55 [Contains: Caspase-2 subunit p18

    • Caspase-2 subunit p13

    • Caspase-2 subunit p12].
      View All» Alternate Names: ICH-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Flow Cytometry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P42575 # Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.SIZE: 452 amino acids; 50685 Da SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.TISSUE SPECIFICITY: Expressed in larger amounts in the embryonic lung, liver and kidney than in the heart and brain. In the adults higher level expression is seen in the placenta, lung, kidney, pancreas than in the heart, brain, liver and skeletal muscle.PTM: The mature protease can process its own propeptide, but not that of other caspases.SIMILARITY: SwissProt: P42575 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Caspase 2 Antibody, clone 11B4 | MAB3507 View All» Concentration: 1 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rat View All»
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