货号：04-1019

品牌：Merck Millipore

规格：

目录价：￥4505.00

市场价格：￥3829.25

会员价格：￥3604.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Synaptophysin (C-term) Antibody, clone YE269, Rabbit | 04-1019 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Synaptophysin at and around the c-terminus. View All» Molecular Weight: ~34 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human Synaptophysin. View All» Clone: YE269 View All» Isotype: IgG View All» Background Information: Synaptophysin is a protein of the presynaptic vesicle exocytosis machinery interacting at the vesicle with VAMP/synaptobrevin. Synaptophysin structure consists of a hexameric protein of four transmembrane spans with cytoplasmic amino and carboxyl termini. Although its actual function remains elusive, synaptophysin remains a specific presynaptic marker for all neurons, neuroendocrine cells and neuroderived neoplasms. View All» Species Reactivity:

• Mouse

• Rat

• Human

• Bovine
  View All» Species Reactivity Note: Human, mouse and rat. Predicted to cross-react with bovine, based on sequence homology. View All» Application Notes: Immunohistochemistry: A 1:250-1:500 dilution of a previous lot of this antibody was used in immunohistochemistry.Immunocytochemistry Analysis: A 1:250 dilution of a previous lot was used in immunocytochemistry. View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot on PC12 cell lysates.Western Blot Analysis: 1:10,000 dilution of this antibody was used to detect Synaptophysin in PC12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P08247 View All» Entrez Gene Number: NM_003179.2 View All» Gene Symbol: synaptophysin View All» Alternate Names: Major synaptic vesicle protein p38 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» UniProt Summary: FUNCTION: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.SUBUNIT STRUCTURE: Homohexamer or homotetramer.SUBCELLULAR LOCATION: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein. Cell junction › synapse › synaptosome. TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.DOMAIN: The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation By similarity.SEQUENCE SIMILARIITES: Belongs to the synaptophysin/synaptobrevin family.Contains 1 MARVEL domain. View All» Product Name: Anti-Synaptophysin (C-term), clone YE269, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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