货号：MAB3514

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Heat Shock Protein 60 Antibody, a.a. 383-447, clone LK1 | MAB3514 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts a 60 kDa protein identified as heat shock protein 60 (hsp60) (Boog et al., 1992). The epitope recognized by MAB3514 is located between amino acids 383-447 of human hsp60 (Boog et al., 1992). CELLULAR LOCALIZATION: Cytoplasmic. View All» Epitope: a.a. 383-447 View All» Immunogen: Recombinant hsp60 protein (Boog et al., 1992). View All» Clone: LK1 View All» Isotype: IgG1 View All» Species Reactivity:

• Chicken

• Human

• Hamster

• Mouse

• Rat
  View All» Application Notes: Immunoblotting: 1-2 μg/mL Immunohistochemistry (frozen and formalin/paraffin): 1-2 μg/mL. Staining of formalin fixed tissue sections requires boiling the tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes. Immunocytochemistry Electron Microscopy (Boog et al., 1992). Immunoprecipitation (Native and denatured): 2 μg antibody/mg of protein lystate using Protein G. Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: BT474, MAD109, RenCa, SK-NEP-1, U937 cells or breast carcinoma. View All» Presentation: Liquid in 10 mM PBS, pH 7.4 with 0.2% BSA and 15 mM sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P10809 View All» Entrez Gene Number:
  • NM_002156.4

  • NM_199440.1
    View All» Gene Symbol:
    • HSPD1

    • HuCHA60

    • chaperonin

    • CPN60

    • SPG13

    • HSP65

    • Hsp60

    • GROEL

    • HSP-60

    • HSP60
      View All» Alternate Names: HSP60 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. View All» UniProt Summary: FUNCTION: SwissProt: P10809 # Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.SIZE: 573 amino acids; 61055 Da SUBUNIT: Interacts with HBV protein X.SUBCELLULAR LOCATION: Mitochondrion matrix.DISEASE: SwissProt: P10809 # Defects in HSPD1 are a cause of spastic paraplegia type 13 (SPG13) [MIM:605280]. SPG13 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.SIMILARITY: SwissProt: P10809 ## Belongs to the chaperonin (HSP60) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Heat Shock Protein 60 Antibody, a.a. 383-447, clone LK1 | MAB3514 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Purified View All» Host: Mouse View All»
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