货号：04-1021

品牌：Merck Millipore

规格：

目录价：￥3767.00

市场价格：￥3201.95

会员价格：￥3013.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ATF-2 (C-term) Antibody, clone E243, Rabbit | 04-1021 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody does not cross-react with other ATF family members. View All» Molecular Weight: ~70 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues in C-terminus of human ATF-2. View All» Clone: E243 View All» Isotype: IgG View All» Background Information: The ATF/CREB family of DNA binding proteins consists of transcription factors whose activity is regulated by specific signaling pathways, including the stress/cytokine/radiation inducible pathways that function through SAPK1/JNK activation. Two threonine residues at positions 69 and 71 in the N-terminal region of ATF-2 are essential in mediating adenovirus E1A-inducible transcriptional activation. These residues are efficiently phosphorylated in vivo and are excellent substrates for SAPK1/JNK in vitro. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:250-500 dilution from a previous lot detected ATF-2 in human breast carcinoma tissue.Immunocytochemistry Analysis: A 1:250-500 dilution from a previous lot was used in IC.Immunoprecipitation Analysis: A 1:60 dilution from a previous lot was used in IP. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot on HeLa cell lysates.Western Blot Analysis: A 1:10,000 dilution of this antibody was used to detect ATF-2 in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P15336 View All» Entrez Gene Number: NM_001880 View All» Gene Symbol:
  • CREB-2

  • CREB2

  • CREBP1

  • HB16

  • MGC111558

  • OTTHUMP00000163262

  • TREB7

  • CRE-BP1
    View All» Alternate Names:
    • Cyclic AMP-responsive element-binding protein 2

    • activating transcription factor 2

    • activating transcription factor 2 splice variant ATF2-var2

    • cAMP response element-binding protein CRE-BP1

    • cAMP responsive element binding protein 2

    • cAMP responsive element binding protein 2, formerly

    • cAMP-dependent transcription factor ATF-2

    • cAMP-responsive element-binding protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.SUBUNIT STRUCTURE: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Abundant expression seen in the brain.PTM: Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK. SEQUENCE SIMILARITIES: Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain.Contains 1 C2H2-type zinc finger.CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator. View All» Product Name: Anti-ATF-2 (C-term), clone E243, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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