货号：04-1032

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurofilament-66 Antibody, clone EP676Y, Rabbit | 04-1032 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neurofilament-66 at and around the tail domain. View All» Molecular Weight: ~66 kDa View All» Epitope: Tail Domain View All» Immunogen: Synthetic peptide corresponding to residues in the tail domain of human Neurofilament-66. View All» Clone: EP676Y View All» Isotype: IgG View All» Background Information: Neurofilament-66, also known as α-internexin, is a member of the IF family. It is found in developing neuroblasts and in the CNS of adults. Neurofilament-66 is expressed in the adult brain at lower levels than other neurofilament proteins. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:250-500 dilution from a previous lot detected Neurofilament-66 in human brain tissue but not in human colon, kidney or uterus.Immunocytochemistry Analysis: A 1:250 - 500 dilution from a previous lot detected Neurofilament-66 in PC12 cells.Flow Cytometry: A 1:25 dilution of a previous lot was used in flow cytometry.Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP. View All» Control: SHSY5Y cell lysate View All» Quality Assurance: Evaluated by Western Blot on SHSY5Y cell lysates.Western Blot Analysis: 1:5,000-10,000 dilution of this antibody was used to detect Neurofilament-66 in SHSY5Y cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q16352 View All» Entrez Gene Number: NP_116116.1 View All» Gene Symbol:
  • Alpha-Inx

  • FLJ18662

  • FLJ57501

  • MGC12702

  • NEF5

  • NF-66

  • Neurofilament-66

  • OTTHUMP00000020403

  • TXBP-1
    View All» Alternate Names:
    • 66 kDa neurofilament protein

    • internexin neuronal intermediate filament protein, alpha

    • neurofilament 5 (66kD)

    • neurofilament-66, tax-binding protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry

      • Immunoprecipitation

      • Flow Cytometry
        View All» Entrez Gene Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. View All» UniProt Summary: FUNCTION: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.TISSUE SPECIFICITY: Found predominantly in adult CNS.DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.PTM: O-glycosylated By similarity.Phosphorylated upon DNA damage, probably by ATM or ATR.SEQUENCE SIMILARITIES: Belongs to the intermediate filament family. View All» Product Name: Anti-Neurofilament-66, clone EP676Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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