货号：04-1038

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aurora C (N-term) Antibody, clone EP1011Y, Rabbit | 04-1038 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Aurora C at and around the N-terminus. View All» Molecular Weight: ~35 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human Aurora C. View All» Clone: EP1011Y View All» Isotype: IgG View All» Background Information: Aurora A, B, and C, are members of the serine/threonine kinase family. These have been identified as important regulators of the mitotic cell division process. Aurora B, specifically, is involved in the regulation of centrosome function, bipolar spindle assembly, and chromosome segregation. Aurora-C is a chromosomal passenger protein that form complexes with Aurora B and INCENP (which binds and activates Aurora C in vivo and in vitro). View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot on HepG2 cell lysates.Western Blot Analysis: A 1:1,000 dilution of this antibody was used to detect Aurora C in HepG2 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q96GD4 View All» Entrez Gene Number: NP_001015878.1 View All» Gene Symbol:

• AIK2

• AIM-1

• AIM1

• ARK2

• Aik2

• AurB

• Aurora-B

• EC 2.7.11.1

• IPL1

• STK-1

• STK12

• STK5

• aurora-1

• aurora-B
  View All» Alternate Names:
  • Aurora- and Ipl1-like midbody-associated protein 1

  • Aurora-related kinase 2

  • Aurora/IPL1-related kinase 2

  • aurora kinase B

  • serine/threonine kinase 12
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium.SUBUNIT STRUCTURE: Interacts with TACC1. Associates with RACGAP1 during M phase. Component of the CPC at least composed of BIRC5/survivin CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with CDCA1 and NDC80. Interacts with EVI5. SUBCELLULAR LOCATION: Nucleus. Centromere. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body.TISSUE SPECIFICITY: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. INVOLVEMENT IN DISEASE: Disruptive regulation of expression is a possibile mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-Aurora C (N-term), clone EP1011Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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