货号：04-1043

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome C Antibody, clone EP1326Y, Rabbit | 04-1043 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Cytochrome C. View All» Molecular Weight: ~14 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human Cytochrome C. View All» Clone: EP1326Y View All» Isotype: IgG View All» Background Information: Cytochrome C is a 15 kDa protein in mitochondria which functions as an electron carrier in the cell respiratory chain by interacting with redox partners of complex III and complex IV. Cytochrome C is highly conserved during evolution. Recent evidence shows that Cytochrome C translocates from mitochondria to the cytosol in the cells undergoing apoptosis and participates in the central control or executioner phase of cell death cascade. Caspase-9 (Apaf-3) and Apaf-1 bind to each other in the presence of Cytochrome C and dATP, an event that leads to Caspase-9 activation. This activation, along with Cytochrome C, plays a major role in the activation of DEVD-specific caspases such as Caspase-3 and DNA fragmentation. Apoptosis inhibitors, Bcl-2 or Bcl-xL, prevent the efflux of Cytochrome C from the mitochondria and Bax, a pro-apoptotic member of the Bcl-2 protein family, can induce Cytochrome C release. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react in human. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 - 250 dilution from a previous lot detected Cytochrome C in human kidney tissue. View All» Control: HeLa, COS, and L929 cell lysates View All» Quality Assurance: Evaluated by Western Blotting on HeLa, COS, and L929 cell lysates.Western Blotting Analysis: 1:500 dilution of this antibody was used to detect Cytochrome C in HeLa, COS, and L929 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P99999 View All» Entrez Gene Number: NP_061820.1 View All» Gene Symbol:

• CYC

• HCS
  View All» Alternate Names:
  • cytochrome c

  • cytochrome c, somatic
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation
      View All» Entrez Gene Summary: This gene encodes cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.SUBCELLULAR LOCATION: Mitochondrion matrix. PTM: Binds 1 heme group per subunit.DISEASE: Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation. SEQUENCE SIMILARITY: Belongs to the cytochrome c family. View All» Product Name: Anti-Cytochrome C, clone EP1326Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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