货号：04-1050

品牌：Merck Millipore

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目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-γ-Synuclein Antibody, clone EP1539Y, Rabbit | 04-1050 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes γ-Synuclein. View All» Molecular Weight: ~16 kDa View All» Immunogen: Synthetic peptide corresponding to residues on γ-Synuclein. View All» Clone: EP1539Y View All» Isotype: IgG View All» Background Information: The synucleins (there is an alpha, beta, and gamma isoform) are small proteins, less than 140 amino acids, which may function in mictotubule assembly and organization. Synucleins with nitrated tyrosine residues are found in the hallmark lesions of Parkinson's and Lewy Body disease. It has been proposed that the formation of aggregates of nitrated proteins may be at least partly responsible for the cytoxicity of these neurodegenerative diseases. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected β-Tubulin in human brain tissue.Immunocytochemistry Analysis: A 1:50-100 dilution from a previous lot was used in IC.Flow Cytometry: A 1:20 dilution of a previous lot was used in flow cytometry.Immunoprecipitation Analysis: A 1:40 dilution from a previous lot was used in IP. View All» Control: Fetal brain lysate View All» Quality Assurance: Evaluated by Western Blot on fetal brain cell lysates.Western Blot Analysis: 1:2,000 dilution of this antibody was used to detect γ-Synuclein in fetal brain cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P37840 View All» Entrez Gene Number: NP_003078.2 View All» Gene Symbol:
  • MGC110988

  • NACP

  • OTTHUMP00000161559

  • OTTHUMP00000161561

  • PARK1

  • PARK4

  • PD1

  • alpha-synuclein
    View All» Alternate Names:
    • Non-A beta component of AD amyloid

    • Non-A4 component of amyloid precursor

    • alpha-synuclein, isoform NACP140

    • non A-beta component of AD amyloid

    • synuclein, alpha (non A4 component of amyloid precursor)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Flow Cytometry

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. View All» UniProt Summary: FUNCTION: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.SUBUNIT STRUCTURE: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 By similarity. Interacts with phospholipase D and histones.SUBCELLULAR LOCATION: Cytoplasm. Membrane. Nucleus. Note: Membrane-bound in dopaminergic neurons. Also found in the nucleus. TISSUE SPECIFICITY: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.DOMAIN: The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments.PTM: Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.INVOLVEMENT IN DISEASE: Defects in SNCA are a cause of autosomal dominant Parkinson disease 1 (PARK1) [MIM:168601, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Defects in SNCA are the cause of Parkinson disease 4 (PARK4) [MIM:605543, 168600].Defects in SNCA are the cause of Lewy body dementia (DLB) [MIM:127750]. DLB is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Presence of Lewy bodies are the only essential pathologic features.Deposition of fibrillar amyloid proteins intraneuronally as neurofibrillary tangles is characteristic of Alzheimer disease (AD). SNCA is a minor protein found within these deposits, but a major non amyloid component.Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCA is found in LB-like inclusions, glial inclusions and spheroids.SEQUENCE SIMILARITIES: Belongs to the synuclein family. View All» Product Name: Anti-γ-Synuclein, clone EP1539Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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