货号：MAB3582

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fascin Antibody, clone 55K2 | MAB3582 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Fascin. The antibody is strongly positive when antigen-presenting dendritic cells are matured. MAB3582 is a sensitive marker for Reed-Sternberg Cells of Hodgkin's Disease. The protein is an actin bundling protein specifically localized in filopodia and growth cones. View All» Immunogen: Human fascin View All» Clone: 55K2 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mammals

• Echinoderms

• Gerbil

• Sea Urchin
  View All» Application Notes: Western blot. Recognizes a protein of 55 kDa. Suggested working dilution is 1:100-1:1,000. Suggested blocking buffer is 3% BSA in PBS or 3% non fat milk in PBS. Immunohistochemistry on formalin fixed, paraffin embedded tissue sections. Suggested working dilution is 1:100-1:1,000. Immunocytochemistry on cold methanol fixed cultured cells. Suggested working dilution is 1:100-1:1,000. Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended: Immunoprecipitation View All» Control: POSITIVE CONTROL: Hela cells, neuronal tissues, antigen presenting dendritic cells. View All» Presentation: Liquid in 0.02M Phosphate buffer with 0.25M NaCl and 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots up to 6 months after date of receipt. View All» UniProt Number: Q16658 View All» Entrez Gene Number: NM_003088.2 View All» Gene Symbol:
  • FSCN1

  • FAN1

  • HSN

  • FLJ38511

  • SNL

  • Fascin

  • p55
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: SwissProt: Q16658 # Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.SIZE: 493 amino acids; 54530 Da SUBUNIT: Associates with beta-catenin.TISSUE SPECIFICITY: Ubiquitous.PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.DISEASE: SwissProt: Q16658 # Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001). Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival, but not bone metastasis-free survival, compared to subjects without the signature.SIMILARITY: SwissProt: Q16658 ## Belongs to the fascin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Fascin Antibody, clone 55K2 | MAB3582 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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