货号：04-1064

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-NMDAR1(Ser889) Antibody, clone EPR2480Y, Rabbit | 04-1064 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects NMDAR1 phosphorylated at Ser889. View All» Molecular Weight: ~120 kDa View All» Epitope: Phosphorylated Ser889 View All» Immunogen: Phospho-specific peptide corresponding to residues surrounding Ser889 of human NMDAR1. View All» Modifications: Phosphorylation View All» Clone: EPR2480Y View All» Isotype: IgG View All» Background Information: Glutamate is a widely utilized excitatory neurotransmitter in mammalian brain. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate (KA) and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are referred to as non-NMDA receptors. Two distinct genes encode the NMDA receptor subunits, NR1 and NR2. The NR1 subunit is expressed in abundance in virtually all regions of the brain. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected NMDAR1 in human brain tissue.Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot was used in IC.Immunoprecipitation Analysis: A 1:30 dilution from a previous lot was used in IP. View All» Control: Mouse brain cell lysate View All» Quality Assurance: Evaluated by Western Blot on untreated and alkaline phosphatase treated mouse brain cell lysates.Western Blot Analysis: 1:1,000-2,000 dilution of this antibody was used to detect NMDAR1 in untreated and alkaline phosphatase treated mouse brain cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q05586 View All» Entrez Gene Number: NP_000823.4 View All» Gene Symbol:
  • NMDA1

  • NMDAR1

  • NR1

  • OTTHUMP00000022678
    View All» Alternate Names:
    • N-methyl-D-aspartate receptor channel, subunit zeta-1

    • N-methyl-D-aspartate receptor subunit NR1

    • NMDA receptor 1

    • glutamate [NMDA] receptor subunit zeta 1

    • glutamate receptor, ionotropic, N-methyl D-aspartate 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. View All» UniProt Summary: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors By similarity.SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ By similarity.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Note: Enriched in post-synaptic plasma membrane and post-synaptic densities By similarity.PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity By similarity.SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification] View All» Product Name: Anti-phospho-NMDAR1(Ser889), clone EPR2480Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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