货号：MAB3632

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Peroxisome Proliferator Activated Receptor γ1 and 2 Antibody, phospho-specific (Ser112) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes phosphorylated Peroxisome Proliferator Activated Receptor (PPAR) gamma1 and gamma2. View All» Epitope: phospho-specific (Ser112) View All» Immunogen: Phosphorylated (serine 112) synthetic peptide from amino acids 107-121 of human PPAR gamma2 (identical to PPAR gamma1). No homology with PPAR alpha or PPAR beta. View All» Modifications: Phosphorylation View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 1:500-1:5,000 on endogenous and recombinant protein. Immunocytochemistry: 1:500-1:5,000 ELISA: 1:500-1:5,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Ascites. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P37231 View All» Entrez Gene Number:
  • NM_005037.5

  • NM_015869.4

  • NM_138711.3

  • NM_138712.3
    View All» Gene Symbol:
    • PPARG

    • NR1C3

    • PPARG2

    • PPAR-gamma

    • PPARG1
      View All» Alternate Names: PPARgamma1 and 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: P37231 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.SIZE: 505 amino acids; 57620 Da SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary.DISEASE: SwissProt: P37231 # Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. & Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]. & Defects in PPARG may be associated with colon cancer. & Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. & Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.SIMILARITY: SwissProt: P37231 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Peroxisome Proliferator Activated Receptor γ1 and 2 Antibody, phospho-specific (Ser112) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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        © Merck Millipore代理MAB3632 Anti-PPAR gamma 1 and 2 Antibody, phospho-specific (Ser112);抗-PPAR γ1和2抗体，磷酸特异性（Ser112）store at -20℃，产品报价联系微信jinshanbio