货号：04-1073

品牌：Merck Millipore

规格：

目录价：￥4645.00

市场价格：￥3948.25

会员价格：￥3716.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, Rabbit | 04-1073 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody only detects GluR1 phosphorylated on Ser845. View All» Molecular Weight: ~106 kDa View All» Epitope: Phosphorylated Ser845 View All» Immunogen: Phospho-specific peptide corresponding to residues surrounding Ser845 of human GluR1. View All» Modifications: Phosphorylation View All» Clone: EPR2148 View All» Isotype: IgG View All» Background Information: Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR1 or GluR3 subunit to be calcium permeable (Hollmann & Heinemann, 1994). The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Control: Rat brain lysate View All» Quality Assurance: Evaluated by Western Blot on untreated and lambda phosphatase treated rat brain cell lysates.Western Blot Analysis: 1:5,000-10,000 dilution of this antibody was used to detect GluR1 in untreated and lambda phosphatase treated rat brain cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P42261 View All» Entrez Gene Number: NP_000818.2 View All» Gene Symbol:
  • GLUH1

  • GLUR1

  • GLURA

  • GluR-1

  • GluR-A

  • GluR-K1

  • HBGR1

  • MGC133252
    View All» Alternate Names:
    • AMPA 1

    • AMPA-selective glutamate receptor 1

    • Glutamate receptor ionotropic, AMPA 1

    • glutamate receptor, ionotropic, AMPA 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» Product Name: Anti-phospho-GluR1 (Ser845), clone EPR2148, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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