货号：04-1081

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium/Calmodulin Kinase IV Antibody, clone EP2564Y, Rabbit | 04-1081 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Calcium/Calmodulin Kinase IV. View All» Molecular Weight: ~60 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human Calcium/Calmodulin Kinase IV. View All» Clone: EP2564Y View All» Isotype: IgG View All» Background Information: The Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV, Phosphorylase Kinase, and MLCK. The CaM Kinases are inactive in the absence of stimuli; binding to Ca2+/Calmodulin induces conformational changes and activation. CaM Kinases have broad substrate specificity, with many cellular functions. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat View All» Application Notes: Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot was used in IC. View All» Control: Jurkat and Human brain lysates View All» Quality Assurance: Evaluated by Western Blot on Jurkat and Human brain lysates.Western Blot Analysis: A 1:1,000-2,000 dilution of this antibody was used to detect Calcium/Calmodulin Kinase IV in Jurkat and Human brain lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q16566 View All» Entrez Gene Number: NM_001744.3 View All» Gene Symbol:
  • CaMK-GR

  • EC 2.7.11.17

  • MGC36771
    View All» Alternate Names:
    • CAM kinase IV

    • CAM kinase- GR

    • CAM kinase-GR

    • CaMK IV

    • brain Ca(2+)-calmodulin-dependent protein kinase type IV

    • brain Ca++-calmodulin-dependent protein kinase type IV

    • calcium/calmodulin-dependent protein kinase IV

    • calcium/calmodulin-dependent protein kinase type IVcatalytic chain
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells View All» UniProt Summary: FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory By similarity.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION:Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca2+/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca2+/calmodulin-independent state By similarity. Probably inactivated by serine/threonine protein phosphatase 2A.SUBUNIT STRUCTURE: Monomer By similarity. Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca2+/calmodulin.SUBCELLULAR LOCATION: Cytoplasm By similarity. Nucleus By similarity. Note: Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix By similarity.TISSUE SPECIFICTY: Expressed in epithelial ovarian cancer tissue. Ref.8PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 By similarity. Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-Calcium/Calmodulin Kinase IV, clone EP2564Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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