货号：04-1087

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HIAP-1/BIR3 Antibody, clone E40, Rabbit | 04-1087 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HIAP-1. View All» Molecular Weight: ~72 kDa View All» Immunogen: Synthetic peptide corresponding to residues of Human HIAP-1. View All» Clone: E40 View All» Isotype: IgG View All» Background Information: HIAP belongs to a family of apoptosis inhibitor proteins that have a baculovirus IAP repeat (BIR). These BIR's interact with TRAF1 and TRAF2 that forms a heteromeric complex. This complex is what is thought to inhibit apoptosis. HIAP is located in the cytoplasm. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Application Notes: Immunohistochemistry Analysis: 1:50 dilution from a previous lot detected HIAP-1/BIR3 in human normal spleen tissue. View All» Control: Daudi cell lysates View All» Quality Assurance: Evaluated by Western Blotting on Daudi cell lysates.Western Blotting Analysis: 1:500 dilution of this antibody was used to detect HIAP-1 in Daudi cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q13489 View All» Entrez Gene Number: NP_001156.1 View All» Gene Symbol:

• AIP1

• API2

• C-IAP2

• CIAP2

• HAIP1

• HIAP-1

• HIAP1

• IAP1

• MALT2

• MIHC

• RNF49

• cIAP2

• hiap-1
  View All» Alternate Names:
  • Apoptosis inhibitor 2

  • IAP homolog C

  • Inhibitor of apoptosis protein 1

  • RING finger protein 49

  • TNFR2-TRAF signaling complex protein

  • TNFR2-TRAF-signaling complex protein 1

  • baculoviral IAP repeat-containing 3

  • baculoviral IAP repeat-containing protein 3

  • mammalian IAP homolog C
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunohistochemistry (Paraffin)

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).SUBUNIT STRUCTURE: Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.SUBCELLULAR LOCATION: CytoplasmPotential. TISSUE SPECIFICITY: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.DISEASE: A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.SEQUENCE SIMILARITY: Belongs to the IAP family. Contains 3 BIR repeats. Contains 1 CARD domain. Contains 1 RING-type zinc finger. View All» Product Name: Anti-HIAP-1/BIR3, clone E40, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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