货号：MAB3732

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-jun Antibody, clone 6A6.2 | MAB3732 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes c-Jun, the cellular homolog of the avian sarcoma virus 17 oncogene, v-jun. It is a member of the transcriptional complex called AP1, a group of related dimeric basic region-leucine zipper proteins belonging to the Jun, Fos, Maf, and ATF subfamilies. c-Jun is activated by phosphorylation by c-Jun-N-terminal kinases (JNKs). View All» Immunogen: Recombinant c-Jun GST fusion protein View All» Clone: 6A6.2 View All» Isotype: IgG2a View All» Background Information: c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun. View All» Species Reactivity: Human View All» Application Notes: Western blot: (1-2 ug/mL) Optimal working dilutions must be determined by end user. View All» Control: NIH-3T3 cells View All» Presentation: Protein A purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P05412 View All» Entrez Gene Number: NM_002228.3 View All» Gene Symbol:

• JUN

• AP1

• p39

• c-Jun
  View All» Alternate Names: Activator Protein 1; AP-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. View All» UniProt Summary: FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.SIZE: 331 amino acids; 35676 Da SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain. View All» Brand Family: Chemicon View All» Product Name: Anti-c-jun Antibody, clone 6A6.2 | MAB3732 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-131299.htm
  © Merck Millipore代理MAB3732 C-JUN,MS X - 100UG，产品报价联系微信jinshanbio