货号：MAB3737

品牌：Merck Millipore

规格：

目录价：￥3853.00

市场价格：￥3275.05

会员价格：￥3082.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR2 Antibody, clone 11G7 | MAB3737 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human TLR2 (Toll-like receptor 2). The 11G7 antibody inhibits the production of inflammatory cytokines, which are produced upon TLR2 stiulation with a select set of TLR2 ligands. These include the TLR2/TLR1 ligands aralipoarabinomannan and Pam3CSK4. In contrast, this antibody does not inhbit the production of cytokines upon stimulation with zymosan, a TLR2/TLR6 ligand. Thus, 11G7 is a selective inhibitor of TLR2 activation (1). View All» Immunogen: Human TLR2 View All» Clone: 11G7 View All» Background Information: Toll-like receptors are cell surface receptors that serve as innate immune responsese to a variety of microbial ligands. View All» Species Reactivity: Human View All» Application Notes: Functional Assays Flow Cytometry Immunoprecipitation ELISA Optimal working dilutions must be determined by end user. View All» Presentation: Ascites fluid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O60603 View All» Entrez Gene Number: NM_003264.3 View All» Gene Symbol:

• TLR2

• CD282

• TIL4
  View All» Alternate Names: Toll-like Receptor 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Flow Cytometry

  • Immunoprecipitation

  • Affects Function
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. View All» UniProt Summary: FUNCTION: SwissProt: O60603 # Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.SIZE: 784 amino acids; 89838 Da SUBUNIT: Binds LY96 and TLR6 via the extracellular domain. Binds MYD88 via their respective TIR domains.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.PTM: Glycosylation of Asn-442 is critical for secretion of the N- terminal ectodomain of TLR2.SIMILARITY: SwissProt: O60603 ## Belongs to the Toll-like receptor family. & Contains 14 LRR (leucine-rich) repeats. & Contains 1 TIR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TLR2 Antibody, clone 11G7 | MAB3737 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-131304.htm
    © Merck Millipore代理MAB3737 TLR2, MS X, 100UL，产品报价联系微信jinshanbio