货号：04-1101

品牌：Merck Millipore

规格：EA

目录价：￥4320.00

市场价格：￥3672.00

会员价格：￥3456.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bcl-10 (C-term.) Antibody, clone EP606Y, Rabbit | 04-1101 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Bcl-10. View All» Molecular Weight: ~32 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues in the C-terminus of human Bcl-10. View All» Clone: EP606Y View All» Isotype: IgG View All» Background Information: Bcl-10 is an adapter protein that promotes apoptosis. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5). View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Application Notes: Immunohistochemistry Analysis: 1:100 - 250 dilution from a previous lot detected Bcl-10 in human hepatocellular carcinoma tissue.Immunocytochemistry: A previous lot was used in immunofluorescent IC analysis. View All» Control: Raji cell lysates View All» Quality Assurance: Evaluated by Western Blotting on Raji cell lysates.Western Blotting Analysis: 1:1,000 - 5,000 dilution of this antibody was used to detect Bcl-10 in Raji cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl with 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: O95999 View All» Entrez Gene Number: NP_003912.1 View All» Gene Symbol:

• Bcl-10

• CARMEN

• CIPER

• CLAP

• Cellular-E10

• OTTHUMP00000011647

• OTTHUMP00000036080

• c-E10

• cCARMEN

• hCLAP

• mE10
  View All» Alternate Names:
  • B-cell CLL/lymphoma 10

  • CARD containing molecule enhancing NF-kB

  • CARD-containing apoptotic signaling protein

  • CARD-containing molecule enhancing NF-kappa-B

  • CARD-containing proapoptotic protein

  • CARD-like apoptotic protein

  • CED-3/ICH-1 prodomain homologous E10-like regulator

  • Cellular homolog of vCARMEN

  • Mammalian CARD-containing adapter molecule E10

  • caspase-recruiting domain-containing protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunohistochemistry (Paraffin)

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]. View All» UniProt Summary: FUNCTION:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. SUBUNIT STRUCTURE: Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2.SUBCELLULAR LOCATION: Cytoplasm › perinuclear region. Note= Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.TISSUE SPECIFICITY:Ubiquitous.PTM: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Ref.9DISEASE: A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Defects in BCL10 are involved in various types of cancer.SEQUENCE SIMILARITY: Contains 1 CARD domain. View All» Product Name: Anti-Bcl-10 (C-term.), clone EP606Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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