货号：MAB3745

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10 | MAB3745 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mouse NKR-P1 cells. Binds to NKR-P1 receptors and induces release of cytokine in SJL/J NK cells. View All» Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cellline. View All» Clone: 1C10 View All» Isotype: IgG1 View All» Background Information: Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. View All» Species Reactivity: Mouse View All» Application Notes: Western blot (1-5 μg/ml) Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in phosphate buffered saline and 0.08% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q12918 View All» Entrez Gene Number: NM_002258.2 View All» Gene Symbol:

• KLRB1

• hNKR-P1A

• MGC138614

• NKRP1A

• NKR-P1

• NKR-P1A

• NKR

• HNKR-P1a

• CLEC5B

• CD161
  View All» Alternate Names: NKR-P1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. View All» UniProt Summary: FUNCTION: SwissProt: Q12918 # Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.SIZE: 225 amino acids; 25415 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).TISSUE SPECIFICITY: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.PTM: N-glycosylated. Contains sialic acid residues.SIMILARITY: SwissProt: Q12918 ## Contains 1 C-type lectin domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10 | MAB3745 View All» Concentration: 1 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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