货号：04-1111

品牌：Merck Millipore

规格：

目录价：￥4352.00

市场价格：￥3699.20

会员价格：￥3481.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NGF Receptor Antibody, clone EP1039Y, Rabbit | 04-1111 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NGF Receptor. View All» Molecular Weight: ~75 kDa View All» Immunogen: Synthetic peptide corresponding to residues of human NGF Receptor. View All» Clone: EP1039Y View All» Isotype: IgG View All» Background Information: Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75 kDa transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:50-100 dilution from a previous lot detected NGF Receptor in human brain glioma tissue.Immunocytochemistry Analysis: A 1:50 dilution from a previous lot was used in IC.Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP. View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot on PC12 cell lysates.Western Blot Analysis: 1:2,000-50,000 dilution of this antibody was used to detect NGF Receptor in PC12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P08138 View All» Entrez Gene Number: NP_002498.1 View All» Gene Symbol:
  • Beta-NGF

  • HSAN5

  • MGC161426

  • MGC161428

  • NGFB

  • NID67

  • OTTHUMP00000013653
    View All» Alternate Names:
    • beta-nerve growth factor

    • nerve growth factor (beta polypeptide)

    • nerve growth factor, beta polypeptide

    • nerve growth factor, beta subunit
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1(By similarity). Interacts with LINGO1SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. The extracellular domain is responsible for interaction with NTRK1 By similarity.SEQUENCE SIMILARITIES: Contains 1 death domain. Contains 4 TNFR-Cys repeats. View All» Product Name: Anti-NGF Receptor, clone EP1039Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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