货号：MAB3773

品牌：Merck Millipore

规格：1EA

目录价：￥5125.68

市场价格：￥4356.83

会员价格：￥4100.54

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Annexin I Antibody, clone 6E4/3 | MAB3773 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Annexin I View All» Immunogen: Whole native annexin proteins contained in a mixture of membrane proteins from human bone tissue View All» Clone: 6E4/3 View All» Isotype: IgG1 View All» Background Information: Annexin I belongs to a family of Ca2+ dependent phospholipid binding proteins. It has been implicated in the regulation of phagocytosis, cell signaling and cell proliferation. View All» Species Reactivity: Human View All» Application Notes: Western blot Immunofluorescence ELISA Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P04083 View All» Entrez Gene Number: NM_000700.1 View All» Gene Symbol:

• ANXA1

• LPC1

• Annexin-1

• Chromobindin-9

• ANX1

• p35
  View All» Alternate Names: Lipocortin I, Calpactin II, Chromobindin 9, Phospholipase A2 Inhibitory Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunofluorescence

  • Western Blotting
    View All» Entrez Gene Summary: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. View All» UniProt Summary: FUNCTION: SwissProt: P04083 # Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.SIZE: 346 amino acids; 38714 Da SUBUNIT: Homodimer in placenta (20%); linked by transglutamylation.SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).DOMAIN: SwissProt: P04083 A pair of annexin repeats may form one binding site for calcium and phospholipid.PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Annexin I Antibody, clone 6E4/3 | MAB3773 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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