货号：MAB3774

品牌：Merck Millipore

规格：

目录价：￥5215.00

市场价格：￥4432.75

会员价格：￥4172.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Annexin II Antibody, clone 3D5/4 | MAB3774 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Annexin II View All» Immunogen: Whole native annexin proteins contained in a mixture of membrane proteins from human bone tissue View All» Clone: 3D5/4 View All» Isotype: IgG2a View All» Background Information: Annexin II belongs to a family of Ca2+ dependent phospholipid binding proteins. It is thought to serve as a profibrinolytic coreceptor for both plasminogen and tissue plasminogen activator on the surface of endothelial cells. It is also known to interact with viral pathogens. View All» Species Reactivity: Human View All» Application Notes: Immunoprecipitation Immunohistochemistry: acetone fixed frozen sections ELISA Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P07355 View All» Entrez Gene Number:

• NM_001002857.1

• NM_001002858.1

• NM_004039.2
  View All» Gene Symbol:
  • ANXA2

  • LPC2D

  • P36

  • p36

  • Chromobindin-8

  • LIP2

  • Annexin-2

  • ANX2L4

  • LPC2

  • ANX2

  • PAP-IV

  • CAL1H
    View All» Alternate Names: Lipocortin II, Calpactin I Heavy Chain, Chromobindin 8 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P07355 # Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.SIZE: 339 amino acids; 38604 Da SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.DOMAIN: SwissProt: P07355 A pair of annexin repeats may form one binding site for calcium and phospholipid.PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats.MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis." View All» Brand Family: Chemicon View All» Product Name: Anti-Annexin II Antibody, clone 3D5/4 | MAB3774 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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