货号：04-1117

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-alpha Tubulin Antibody, clone EP1332Y, Rabbit | 04-1117 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes alpha Tubulin. View All» Molecular Weight: ~ 50 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human alpha Tubulin. View All» Clone: EP1332Y View All» Isotype: IgG View All» Background Information: Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein which consists of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22 nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation which is characteristic for microtubules in neuronal cells and the mitotic spindle. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:250 - 500 dilution from a previous lot detected alpha Tubulin in human gastric carcinoma tissue.Immunocytochemistry Analysis: 1:250 - 500 dilution from a previous lot detected alpha Tubulin in HeLa cell lysate.Immunoprecipitation: 1:50 dilution from a previous lot was used on IP.Flow Cytometry: 1:20 dilution from a previous lot was used on FC. View All» Control: HeLa cell lysate. View All» Quality Assurance: Evaluated by Western Blot on HeLa cell lysate.Western Blot Analysis: 1:50,000 dilution of antibody was used to detect alpha Tubulin in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-glycine (pH 7.4), 0.18 M NaCl containing 40% glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM citric acid, and 0.5% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q71U36 View All» Entrez Gene Number: P68363 View All» Gene Symbol:
  • B-ALPHA-1

  • FLJ25113

  • LIS3

  • TUBA3

  • hum-a-tub1

  • hum-a-tub2
    View All» Alternate Names:
    • Alpha-tubulin 3

    • Tubulin B-alpha-1

    • Tubulin alpha-3 chain

    • tubulin, alpha 1a

    • tubulin, alpha 3

    • tubulin, alpha, brain-specific
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.SUBUNIT STRUCTURE: Dimer of alpha and beta chains.TISSUE SPECIFICITY: Expressed at a high level in fetal brain. PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively By similarity.INVOLVEMENT IN DISEASE: Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem. SEQUENCE SIMILARITIES: Belongs to the tubulin family. View All» Product Name: Anti-alpha Tubulin, clone EP1332Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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