货号：MAB3778

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HGF/SF Antibody, clone 4C12.1 | MAB3778 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Human Hepatocyte Growth Factor/ Scatter Factor (HGF/SF) View All» Immunogen: Recombinant Human HGF/SF View All» Clone: 4C12.1 View All» Isotype: IgG2b View All» Background Information: HGF/SF is a member of the plasminogen related growth factor family, members of which are potent effectors of growth, movement and differentiation of epithelial and endothelial cells. HGF/SF may exhibit morphogenesis in adjacent cells. The membrane receptor for HGF/SF is the product of the proto-oncogene c-met, a receptor tyrosine kinase. View All» Species Reactivity: Human View All» Application Notes: ELISA Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P05231 View All» Entrez Gene Number: NM_000600.2 View All» Gene Symbol:

• IL6

• IL-6

• HSF

• BSF2

• BSF-2

• CDF

• IFNB2

• HGF
  View All» Alternate Names: Hepatocyte Growth Factor/Scatter Factor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: ELISA View All» UniProt Summary: FUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.SIZE: 212 amino acids; 23718 Da SUBCELLULAR LOCATION: Secreted.PTM: N- and O-glycosylated.DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-HGF/SF Antibody, clone 4C12.1 | MAB3778 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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