货号：04-1125

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Rsk3 (Thr353/Thr356) Antibody, clone E202, Rabbit | 04-1125 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody only detects Rsk phosphorylated on Thr353 and Thr356. View All» Molecular Weight: ~90 kDa View All» Epitope: Phosphorylated Thr353/Thr356 View All» Immunogen: Phospho-synthetic peptide corresponding to residues surrounding Thr353 and Thr356 of human Rsk3. View All» Modifications: Phosphorylation View All» Clone: E202 View All» Isotype: IgG View All» Background Information: Rsk1, Rsk2, and Rsk3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases, and are alternatively referred to as MAPKAP kinases 1a, 1b, and 1c. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. Rsk1 activation can be monitored by phosphorylation state specific antibodies directed against sites involved in its activation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Western Blot Analysis: A 1:5,000-20,000 dilution from a previous lot was used in WB.Immunocytochemistry Analysis: A 1:50-100 dilution from a previous lot was used in IC.Immunoprecipitation Analysis: A 1:100 dilution from a previous lot was used in IP. View All» Control: Human prostate carcinoma tissue View All» Quality Assurance: Evaluated by Immunohistochemistry on human prostate carcinoma.Immunohistochemistry Analysis: A 1:50-100 (antigen retrieval required) dilution of this antibody was used to detect Rsk3 in prostate carcinoma tissue. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q15349 View All» Entrez Gene Number: NP_001006933.1 View All» Gene Symbol:
  • EC 2.7.11.1

  • HU-2

  • MAPKAPK1C

  • RSK

  • RSK-3

  • RSK3

  • S6K-alpha

  • S6K-alpha2

  • p90-RSK3

  • pp90RSK3
    View All» Alternate Names:
    • 90 kDa ribosomal protein S6 kinase 2

    • MAP kinase-activated protein kinase 1c

    • Ribosomal S6 kinase 3

    • S6K-alpha 2

    • p90-RSK 2

    • ribosomal protein S6 kinase alpha 2

    • ribosomal protein S6 kinase, 90kD, polypeptide 2

    • ribosomal protein S6 kinase, 90kDa, polypeptide 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUCNTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium.ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues By similarity.SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation By similarity.SUBCELLULAR LOCATION: Nucleus TISSUE SPECIFICITY: Expressed in many tissues. Highest expression in lung and skeletal muscle. PTM: Autophosphorylated on Ser-377, as part of the activation process By similarity. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains. View All» Product Name: Anti-phospho-Rsk3 (Thr353/Thr356), clone E202, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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