货号：04-1128

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Casein Kinase II (beta subunit) Antibody, clone EP1995Y, Rabbit | 04-1128 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Casein Kinase II (beta subunit). View All» Molecular Weight: ~24 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the C-terminus of human Casein Kinase II (beta subunit). View All» Clone: EP1995Y View All» Isotype: IgG View All» Background Information: Unlike most serine/threonine kinases, Casein Kinases (CKs) are not activated by specific stimuli, but are essentially constitutively active. CK1 autophosphorylates, causing inactivation, and protein phosphatases reactivate the kinase. The substrates of CKs are numerous, but their function is less clear, perhaps due to the absence of obvious regulation. CK1 isoforms are thought to be involved in the response to DNA damage, while CK2 levels are elevated in many types of cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Casein Kinase II (beta subunit) in human ovary carcinoma tissue.Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot detected Casein Kinase II (beta subunit) in HeLa cells.Flow Cytometry: A 1:20 dilution of a previous lot was used in flow cytometry. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot on K562 cell lysates.Western Blot Analysis: A 1:500-2,000 dilution of this antibody was used to detect Casein Kinase II (beta subunit) in K562 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P67870 View All» Entrez Gene Number: NP_001311.3 View All» Gene Symbol:
  • CK2B

  • CK2N

  • CSK2B

  • G5A

  • G5a

  • MGC138222

  • MGC138224

  • OTTHUMP00000029060

  • OTTHUMP00000029063

  • OTTHUMP00000029064

  • Phosvitin

  • phosvitin
    View All» Alternate Names:
    • CK II beta

    • Casein kinase II beta subunit

    • alternative name: G5a, phosvitin

    • casein kinase 2, beta polypeptide
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry

      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. View All» UniProt Summary: FUNCTION: Participates in Wnt signaling By similarity. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. SUBUNIT STRUCTURE: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 By similarity. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. PTM: Phosphorylated by alpha subunit. SEQEUNCE SIMILARITIES: Belongs to the casein kinase 2 subunit beta family. View All» Product Name: Anti-Casein Kinase II (beta subunit), clone EP1995Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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