货号：04-1129

品牌：Merck Millipore

规格：

目录价：￥3580.00

市场价格：￥3043.00

会员价格：￥2864.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Casein Kinase II (alpha subunit) Antibody, clone EP1963Y, Rabbit | 04-1129 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Casein Kinase II (alpha subunit). View All» Molecular Weight: ~42 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human Casein Kinase II (alpha subunit). View All» Clone: EP1963Y View All» Isotype: IgG View All» Background Information: Unlike most serine/threonine kinases, Casein Kinases (CKs) are not activated by specific stimuli, but are essentially constitutively active. CK1 autophosphorylates, causing inactivation, and protein phosphatases reactivate the kinase. The substrates of CKs are numerous, but their function is less clear, perhaps due to the absence of obvious regulation. CK1 isoforms are thought to be involved in the response to DNA damage, while CK2 levels are elevated in many types of cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:50-100 dilution from a previous lot detected Casein Kinase II (alpha subunit) in human breast carcinoma tissue.Flow Cytometry: A 1:20 dilution of a previous lot was used in flow cytometry. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot on HeLa cell lysates.Western Blot Analysis: A 1:500-1,000 dilution of this antibody was used to detect Casein Kinase II (alpha subunit) in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P68400 View All» Entrez Gene Number: NM_001895.3 View All» Gene Symbol:
  • CK2A1

  • CKII

  • EC 2.7.11.1

  • OTTHUMP00000029925

  • OTTHUMP00000029926
    View All» Alternate Names:
    • CK II

    • CK2 catalytic subunit alpha

    • casein kinase 2, alpha 1 polypeptide

    • casein kinase II alpha 1 subunit

    • protein kinase CK2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUCNTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBUNIT STRUCTURE: Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-Casein Kinase II (alpha subunit), clone EP1963Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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