货号：MAB3784

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AP-2 α/β Antibody, clone A6/2/2 | MAB3784 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human AP-2 alpha and β forms. View All» Immunogen: Synthetic peptide corresponding to the C-terminal region of AP-2alpha (PNSHTDNNAKSSDKEEKHRK). View All» Clone: A6/2/2 View All» Isotype: IgG1 View All» Background Information: AP-2 is a family of developmentally regulated transcription factors, which also play a role in breast cancer and melanoma. AP-2β may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: fixative formal saline with calcium paraffin embedded (10min microwave treatment required) Western blot Radioimmunoassay ELISA FACS Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Raji cells or breast carcinoma View All» Presentation: Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P05549 View All» Entrez Gene Number:

• NM_001032280.2

• NM_001042425.1

• NM_003220.2
  View All» Gene Symbol:
  • TFAP2A

  • TFAP2

  • AP-2

  • AP2TF

  • AP2-alpha

  • AP-2alpha
    View All» Alternate Names: Transcription Factor AP-2 alpha/beta View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Flow Cytometry

    • Radioimmunoassay

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P05549 # Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle (By similarity).SIZE: 437 amino acids; 48062 Da SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis.SUBCELLULAR LOCATION: Nucleus.DOMAIN: SwissProt: P05549 The WW-binding motif mediates interaction with WWOX (By similarity).PTM: Sumoylated on Lys-10; which inhibits transcriptional activity (Probable).SIMILARITY: Belongs to the AP-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-AP-2 α/β Antibody, clone A6/2/2 | MAB3784 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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