货号：04-1132

品牌：Merck Millipore

规格：

目录价：￥3416.00

市场价格：￥2903.60

会员价格：￥2732.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rsk4 (N-term) Antibody, clone EP1982Y, Rabbit | 04-1132 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Rsk4. View All» Molecular Weight: ~90 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human Rsk4. View All» Clone: EP1982Y View All» Isotype: IgG View All» Background Information: Rsk1, Rsk2, Rsk3, and Rsk4 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. RSK4 is mostly expressed in brain and kidney. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:50-100 dilution from a previous lot detected Rsk4 in human brain glioma tissue.Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot detected Rsk4 in SHSY5Y cells.Flow Cytometry: A 1:25 dilution of a previous lot was used in flow cytometry. View All» Control: SHSY5Y cell lysate View All» Quality Assurance: Evaluated by Western Blot on SHSY5Y cell lysates.Western Blot Analysis: A 1:250-500 dilution of this antibody was used to detect Rsk4 in SHSY5Y cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9UK32 View All» Entrez Gene Number: NP_055311.1 View All» Gene Symbol:
  • EC 2.7.11.1

  • OTTHUMP00000023618

  • PP90RSK4

  • RSK-4

  • RSK4

  • pp90RSK4
    View All» Alternate Names:
    • 90 kDa ribosomal protein S6 kinase 6

    • Ribosomal S6 kinase 4

    • S6K-alpha 6

    • p90-RSK 6

    • ribosomal protein S6 kinase polypeptide 6

    • ribosomal protein S6 kinase, 90kD, polypeptide 6

    • ribosomal protein S6 kinase, 90kDa, polypeptide 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)

      • Flow Cytometry
        View All» Entrez Gene Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. View All» UniProt Summary: FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium By similarity.ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues By similarity.SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation By similarity.PTM: Autophosphorylated on Ser-389, as part of the activation process By similarity. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains. View All» Product Name: Anti-Rsk4 (N-term), clone EP1982Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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