货号：MAB379

品牌：Merck Millipore

规格：100UL

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5 | MAB379 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes an epitope common to Glutamate Receptors 5, 6 and 7. No reactivity seen to GluR1, GluR2, GluR3 or GluR4. View All» Immunogen: Recombinant fusion protein TrpE-GluR5 View All» Clone: 4F5 View All» Isotype: IgM View All» Species Reactivity:

• Human

• Monkey

• Rat
  View All» Application Notes: Immunohistochemistry on 4% paraformaldehyde fixed tissue:1:1,000-1:2,000 Immunocytochemistry ELISA RIA Optimal working dilutions must be determined by end user. View All» Presentation: Ascites. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number:
  • P39086

  • Q38PU4

  • P22756
    View All» Entrez Gene Number: NM_000830.3 View All» Gene Symbol:
    • GRIK1

    • Glutamate receptor, ionotropic kainate 1

    • GluR-5

    • GluR5

    • Excitatory amino acid receptor 3

    • EAA3
      View All» Alternate Names: GluR5/6/7 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunocytochemistry

      • Immunohistochemistry

      • Radioimmunoassay
        View All» Entrez Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG>CGG; Q>R) within the second transmembrane domain, whiich is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. View All» UniProt Summary: FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. View All» Brand Family: Chemicon View All» Product Name: Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5 | MAB379 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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