货号：04-1142

品牌：Merck Millipore

规格：

目录价：￥4352.00

市场价格：￥3699.20

会员价格：￥3481.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-pro-NGF (N-term) Antibody, clone EP1318Y, Rabbit | 04-1142 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NGF-β precursor (pro-NGF) at and around the N-terminus. View All» Molecular Weight: ~26 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human NGF-β precursor (pro-NGF). View All» Clone: EP1318Y View All» Isotype: IgG View All» Background Information: Nerve growth factor-beta (NGF-β) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human beta-NGF is is a noncovalently disulfide-linked homodimer, formed by two 13.5 kDa polypeptide monomers (238 total amino acids). The three disulfide bonds are required for biological activity. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:100-250 dilution from a previous lot was used in IC.Flow Cytometry: 1:200 dilution of a previous lot was used in flow cytometry.Immunoprecipitation Analysis: 1:20 dilution from a previous lot was used in IP. View All» Control: Recombinant protein View All» Quality Assurance: Evaluated by Western Blot on recombinant protein.Western Blot Analysis: 1:1,000-5,000 dilution of this antibody was used to detect NGF-β precursor (pro-NGF). View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P01138 View All» Entrez Gene Number: NP_002497.2 View All» Gene Symbol:
  • Beta-NGF

  • HSAN5

  • MGC161426

  • MGC161428

  • NGFB

  • NID67

  • OTTHUMP00000013653
    View All» Alternate Names:
    • beta-nerve growth factor

    • nerve growth factor (beta polypeptide)

    • nerve growth factor, beta polypeptide

    • nerve growth factor, beta subunit
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. View All» UniProt Summary: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.SUBUNIT STRUCTURE: Homodimer.SUBCELLULAR LOCATION: Secreted. INVOLVEMENT IN DISEASE: Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. SEQUENCE SIMILARITIES: Belongs to the NGF-beta family. View All» Product Name: Anti-pro-NGF (N-term), clone EP1318Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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