货号：04-1148

品牌：Merck Millipore

规格：

目录价：￥4505.00

市场价格：￥3829.25

会员价格：￥3604.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-NMDAR2B (Ser1303) Antibody, clone EP1858Y, Rabbit | 04-1148 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects NMDAR2B phosphorylated at Ser1303. View All» Molecular Weight: ~180 kDa View All» Epitope: Phosphorylated Ser1303 View All» Immunogen: Phospho-specific peptide corresponding to residues surrounding Ser1303 of human NMDAR2B. View All» Modifications: Phosphorylation View All» Clone: EP1858Y View All» Isotype: IgG View All» Background Information: Glutamate is a widely utilized excitatory neurotransmitter in mammalian brain. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate (KA) and -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are referred to as non-NMDA receptors. Two distinct genes encode the NMDA receptor subunits, NR1 and NR2. The NR1 subunit is expressed in abundance in virtually all regions of the brain. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:100 dilution from a previous lot was used in IC. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by Western Blot on untreated and alkaline phosphatase treated mouse brain lysates.Western Blot Analysis: 1:1,000-5,000 dilution of this antibody was used to detect phosphorylated NMDAR2B in untreated and alkaline phosphatase treated mouse brain lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q13224 View All» Entrez Gene Number: NP_000825.2 View All» Gene Symbol:
  • MGC142178

  • MGC142180

  • NMDAR2B

  • NR2B

  • NR3

  • hNR3
    View All» Alternate Names:
    • N-methyl D-aspartate receptor subtype 2B

    • N-methyl-D-aspartate receptor subunit 2B

    • N-methyl-D-aspartate receptor subunit 3

    • glutamate receptor subunit epsilon-2

    • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. View All» UniProt Summary: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 By similarity. Interacts with MAGI3.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification] View All» Product Name: Anti-phospho-NMDAR2B (Ser1303), clone EP1858Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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