货号：04-1153

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C/EBP β (C-term) Antibody, clone E299, Rabbit | 04-1153 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody can recognize three C/EBP β isoforms (i.e. LAP*, LAP, and LIP). View All» Molecular Weight: ~38/35/20 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues in C-terminus of rat C/EBP β. View All» Clone: E299 View All» Isotype: IgG View All» Background Information: The transcription factor CCAAT/Enhancer Binding Protein beta (C/EBPβ, also known as NFIL6) is a highly conserved B-Zip family member. C/EBPβ regulates multiple genes involved in hepatic function, immune function and adipogenesis, and its functions are generally distinct from those of other C/EBP family members (alpha, gamma, delta, epsilon). C/EBPβ is present in cells as three alternate translation products: two transcription activating forms known as LAP1 and LAP2 (~35 and 32 kDa in rodents, ~43 kDa and 40 kDa in humans) and a truncated inhibitory form known as LIP (~20 kDa) which lacks the N-terminal transcription activation domain. C/EBP β is phosphorylated at multiple sites which are determinants of some of its activities (e.g. activation of c-fos, adipogenesis). A recent report shows that it is acetylated at Lys215/216, and others report that it can be sumoylated. C/EBPβ is also acetylated at Lys39 in the transcription activation domain, and mutation of Lys39 impairs its ability to activate transcription of multiple genes, including several involved in adipogenesis. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:50-100 dilution from a previous lot detected C/EBP β in HeLa cells.Immunoprecipitation Analysis: A 1:20 dilution from a previous lot was used in IP. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot on PC12 cell lysates.Western Blot Analysis: A 1:1,000 dilution of this antibody was used to detect C/EBP β in PC12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P17676 View All» Entrez Gene Number: NP_077039.3 View All» Gene Symbol:
  • C/EBP-beta

  • CRP2

  • IL6DBP

  • LAP

  • MGC32080

  • NF-IL6

  • NFIL6

  • TCF5
    View All» Alternate Names:
    • C/EBP beta

    • CCAAT/enhancer binding protein (C/EBP), beta

    • CCAAT/enhancer binding protein beta

    • Nuclear factor NF-IL6

    • Transcription factor 5

    • interleukin 6-dependent DNA-binding protein

    • liver-enriched transcriptional activator protein

    • nuclear factor of interleukin 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: transcription factor that binds to CCAATT motif on DNA and may facilitate IL-6 induced transcriptional activation View All» UniProt Summary: FUNCTION: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation By similarity.SUBUNIT STRUCTURE: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B By similarity.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed at low levels in the lung, kidney and spleen.PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. SEQUENCE SIMILARITIES: Belongs to the bZIP family. C/EBP subfamily.Contains 1 bZIP domain. View All» Product Name: Anti-C/EBP β (C-term), clone E299, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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