货号：04-1158

品牌：Merck Millipore

规格：EA

目录价：￥3550.00

市场价格：￥3017.50

会员价格：￥2840.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium/Calmodulin Kinase I Antibody, clone EPR2217Y, Rabbit | 04-1158 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Calcium/Calmodulin Kinase I. View All» Molecular Weight: ~41 kDa View All» Epitope: N-terminus View All» Immunogen: Specific peptide corresponding to residues on the N-terminus of human Calcium/Calmodulin Kinase I. View All» Clone: EPR2217Y View All» Isotype: IgG View All» Background Information: The Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV, Phosphorylase Kinase, and MLCK. The CaM Kinases are inactive in the absence of stimuli; binding to Ca2+/Calmodulin induces conformational changes and activation. CaM Kinases have broad substrate specificity, with many cellular functions. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Calcium/Calmodulin Kinase I in human kidney tissue.Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot was used in IC. View All» Control: Human brain, mouse brain, rat brain, and SHSY5Y lysates View All» Quality Assurance: Evaluated by Western Blot on Human brain, mouse brain, rat brain, and SHSY5Y lysates.Western Blot Analysis: A 1:5,000-10,000 dilution of this antibody was used to detect Calcium/Calmodulin Kinase I in Human brain, mouse brain, rat brain, and SHSY5Y lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q96RR4 View All» Entrez Gene Number: NP_003647.1 View All» Gene Symbol:
  • CAMKK

  • CAMKKB

  • EC 2.7.11.17

  • KIAA0787

  • MGC15254
    View All» Alternate Names:
    • CAMKK beta protein

    • CaM-KK beta

    • CaM-kinase kinase beta

    • CaMKK beta

    • Calcium/calmodulin-dependent protein kinase kinase beta

    • calcium/calmodulin-dependent protein kinase beta

    • calcium/calmodulin-dependent protein kinase kinase 2 beta

    • calcium/calmodulin-dependent protein kinase kinase 2, beta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activate calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. View All» UniProt Summary: FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 By similarity. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.SUBUNIT STRUCTURE: Interacts with calmodulin By similarity.SUBCELLULAR LOCATION: Cytoplasm By similarity. TISSUE SPECFICITY: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.PTM: Autophosphorylated By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.SEQUENCE CAUTION: The sequence CAD38990.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. View All» Product Name: Anti-Calcium/Calmodulin Kinase I, clone EPR2217Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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