货号：MAB388-100UG

品牌：Merck Millipore

规格：100Ug

目录价：￥6138.00

市场价格：￥5217.30

会员价格：￥4910.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myelin Proteolipid Protein Antibody, C-terminus, clone PLPC1 | MAB388-100UG View All» Replaces: MAB388 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with myelin proteolipid protein in many mammalian species. Shows cross-reactivity to DM20. View All» Molecular Weight: 23-25 kDa View All» Epitope: C-terminus View All» Immunogen: Myelin proteolipid protein, synthetic peptide CGRGTKF corresponding to the C-terminal peptide. View All» Clone: PLPC1 View All» Isotype: IgG2a View All» Species Reactivity: Mammals View All» Application Notes: Western Blotting: detects a 23-25kDa protein and DM20 a 20kDa protein; PLP can aggregate causing HMW bands to sometimes appear in certain preparations. Immunocytochemistry: 4% PFA fixed cells, 5-10 minutes room temperature. Use 0.1% triton in block only to allow antibody access to C-terminal epitope. Immunohistology on fresh frozen sections or 4% PFA fixed, frozen tissues. Epitope is internal, use 0.1-0.2% triton X-100 in the blocking step for permeabilization. Immunohistochemistry in paraffin: works best with lightly fixed tissues, or Bouin's fixed material, although there are reports of traditional formalin fixation also working with antigen recovery. {Mathis, et al 2003}. Optimal working dilutions must be determined by end user. View All» Control: Brain View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse immunoglobulin in PBS, pH 7.2 containing 0.09% sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P60201 View All» Entrez Gene Number: NM_000533.3 View All» Gene Symbol:

• PLP

• PMD

• MMP

• SPG2

• PLP/DM20
  View All» Alternate Names: PLP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Immunohistochemistry (Paraffin)

  • Western Blotting
    View All» Entrez Gene Summary: This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.SIZE: 277 amino acids; 30,077 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.PTM: Lipoprotein, PalmitateDISEASE:Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia.SIMILARITY: Belongs to the myelin proteolipid protein family. View All» Brand Family: Chemicon View All» Product Name: Anti-Myelin Proteolipid Protein Antibody, C-terminus, clone PLPC1 | MAB388-100UG View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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