货号：04-135

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Brachyury Antibody, clone 3E4.2 | 04-135 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This monoclonal antibody recognizes the brachyury protein. View All» Molecular Weight: 47 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic human brachyury peptide, a.a. 224-435. View All» Clone: 3E4.2 View All» Isotype: IgG1κ View All» Background Information: The Brachyury protein is a T-box transcription factor that is one of the earliest indicators of mesoderm formation during embryonic development. As the brachyury protein family is essential for the formation of the posterior body in all vertebrates, Brachyury has been shown to be expressed during gastrula and neurula stages, as well as in the developing notochord. Consequently, when mutations occur within the brachyury gene, severe vertebral malformations have been found to occur, as a direct result. In addition, current findings also indicate that the dysregulation of brachyury may also be linked to the formation of chordomas, which are malignant tumors that develop along the spine. View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with human. Reactivity with other species has not been tested. View All» Quality Assurance: Routinely evaluated by Western blot on NT2 cell lysates.Western Blotting: Recommended working dilutions are 1:1000. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: O15178 View All» Entrez Gene Number: NP_003172 View All» Gene Symbol:

• MGC104817

• OTTHUMP00000017588

• TF

• TFT
  View All» Alternate Names:
  • T brachyury (mouse) homolog

  • T brachyury-like

  • T protein

  • T, brachyury homolog (mouse)

  • transcription factor T
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. View All» UniProt Summary: FUNCTION: SwissProt: O15178 # Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.SIZE: 435 amino acids; 47443 Da SUBUNIT: Monomer (By similarity). Nucleus.DISEASE: SwissProt: O15178 # Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.SIMILARITY: SwissProt: O15178 ## Contains 1 T-box DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-Brachyury, clone 3E4.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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