货号：04-145

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NOD2 Antibody, clone 2D9 | 04-145 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NOD2. View All» Molecular Weight: ~110 kDa View All» Epitope: Unknown View All» Immunogen: His-tagged recombinant protein corresponding to human NOD2. View All» Clone: 2D9 View All» Isotype: IgG1κ View All» Background Information: NOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Control: Hyperplastic colorectal carcinoma tissue View All» Quality Assurance: Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HC29 View All» Entrez Gene Number: NP_071445 View All» Gene Symbol:

• NOD2

• ACUG

• BLAU

• CARD15

• CD

• CLR16.3

• IBD1

• NLRC2

• NOD2B

• PSORAS1
  View All» Alternate Names:
  • Caspase recruitment domain-containing protein 15

  • Inflammatory bowel disease protein 1

  • NLR family, CARD domain containing 2

  • NOD-like receptor C2

  • caspase recruitment domain family, member 15

  • caspase recruitment domain protein 15

  • nucleotide-binding oligomerization domain 2

  • nucleotide-binding oligomerization domain containing 2

  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn's disease and Blau syndrome. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).SUBUNIT STRUCTURE: Binds to RICK by CARD-CARD interaction.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Monocytes-specific.INVOLVEMENT IN DISEASE: Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash. Defects in NOD2 are a cause of susceptibility to Crohn's disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn's disease is commonly classified as autoimmune disease. Defects in NOD2 are a cause of susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease.Defects in NOD2 are the cause of early-onset sarcoidosis (EOS) [MIM:609464]. Sarcoidosis is a multiorganic inflammatory disease with unknown etiology, characterized by the histologic features of non-caseating epithelioid granulomas. In childhood, 2 distinct types of sarcoidosis have been described. Usually the disease is detected in older children by chest radiography and the clinical manifestations are characterized by a classical triad of lung, lymph node, and eye involvement, similar to those in adults. In contrast, early-onset sarcoidosis (EOS), which usually appears in those younger than 4 years of age, is quite rare and has a distinct triad of skin, joint, and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, EOS is progressive and in many cases causes severe complications, such as blindness, joint destruction, and visceral involvement. SEQUENCE SIMLARITIES: Contains 2 CARD domains.Contains 6 LRR (leucine-rich) repeats.Contains 1 NACHT domain. View All» Product Name: Anti-NOD2, clone 2D9 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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