货号：04-146

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NLRX1 Antibody | 04-146 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~107 kDa observed View All» Immunogen: Histidine-tagged recombinant protein corresponding to human NLRX1. View All» Isotype: IgG2aκ View All» Background Information: NLR family member X1 (NLRX1) belongs to the Nod-like receptor (NLR) family of proteins, a group of proteins characterized by their highly conserved nucleotide binding domain (NBD) and their leucine-rich-repeats (LRR). NLRX1 is the only member of this family localized to mitochondria, where it plays a role in antiviral signaling by blocking virus-induced interaction of RLH-MAVS, serving as a negative regulator of the antiviral responses mediated by MAVS. It also serves to up-regulate NF-Kappa-B and JNK-dependent signaling cascades as its overexpression induces reactive oxygen species (ROS). NLRX1 has been observed in high quantities within the heart, mammary gland, and muscle tissues. It has also been observed at the protein level in various cell lines including; JURKAT, HeLa, HL60, RAJI, THP-1, and 293T. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF to detect NLRX1 in the mitochondria of the cytosol (Moore, C. B., Ting, J.P-Y., et al., 2008).Immunogold-bead Electron Micrography: A previous lot was used by an independent laboratory to detect NLRX1 in the outer mitochondrial membrane by electron micrography (Moore, C. B., Ting, J.P-Y., et al., 2008). View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected NLRX1 in 10 µg of HeLa cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q86UT6 View All» Entrez Gene Number: NP_078894 View All» Gene Symbol:

• NOD26

• NOD9

• NLRX1

• DLNB26

• NOD5
  View All» Alternate Names:
  • NLR family member X1

  • NLR family, X1

  • Nucleotide-binding oligomerization domain protein 9

  • Caterpiller protein 11.3

  • Nucleotide-binding oligomerization domain protein 5

  • NOD-like receptor X1

  • Nucleotide-binding oligomerization domain protein 26

  • nucleotide-binding oligomerization domain, leucine rich repeat containing X1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (Ref.9). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (Ref.8). SUBUNIT STRUCTURE: Interacts with MAVS. SUBCELLULAR LOCATION: Mitochondrion outer membrane TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level). SEQUENCE SIMILARITIES: Belongs to the NLRP family.Contains 4 LRR (leucine-rich) repeats.Contains 1 NACHT domain.SEQUENCE CAUTION: The sequence BAB15075.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG51714.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG51714.1 differs from that shown. Reason: Erroneous termination at position 951. Translated as Trp. View All» Product Name: Anti-NLRX1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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